Progranulin Promotes Bleomycin-Induced Skin Sclerosis by Enhancing Transforming Growth Factor–β/Smad3 Signaling through Up-Regulation of Transforming Growth Factor–β Type I Receptor
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چکیده
منابع مشابه
De-ubiquitinating enzyme, USP11, promotes transforming growth factor β-1 signaling through stabilization of transforming growth factor β receptor II
The transforming growth factor β-1 (TGFβ-1) signaling pathway plays a central role in the pathogenesis of pulmonary fibrosis. Two TGFβ-1 receptors, TβRI and TβRII, mediate this pathway. TβRI protein stability, as mediated by the ubiquitin/de-ubiquitination system, has been well studied; however, the molecular regulation of TβRII still remains unclear. Here we reveal that a de-ubiquitinating enz...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2019
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2019.04.012